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Vaccination Safety

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Vaccination Safety

Vaccines protect individuals and the public from life-threatening, preventable diseases. Healthy individuals, as well as the most vulnerable, benefit from vaccinations. Nurses should be well-informed about safe and unsafe injection practices, including proper use and disposal, as well as understand potential risks and strategies to prevent injury or contamination.

Multi-dose Vials

Recognizing the differences between single-dose and multiple-dose vials and to understand appropriate use of each container type.

How Do I Safely Use a Multi-Dose Vaccine Vial? Part 2
How Do I Safely Use a Multi-Dose Vaccine Vial? Part 1
Safety Steps for Giving Vaccines from Multi-dose Vials
Multi-dose Vaccine Vial Safety Checklist

Injection Safety

Adhering to injection safety best practices is critical to nurse and patient safety.

WHO Best Practices for Injections and Related Procedures Toolkit
First, do no harm
Injection Safety for COVID-19 Vaccinators & Vaccine Administrators
Preventing Needlesticks
Sharps Safety for Healthcare Settings
One & Only Campaign
Sharps Injury Prevention
Injection Safety Pain Clinics
Safe Injections Cancer Clinics
Safe Injections for Patients
Injection Safety Checklist
Injection Safety Guidelines
Sharp Safety Poster Now you see it
Sharp Safety Poster Begins with You
Safe Injection Myths
Safe Injection Handout
Injection Safety Video
Safe Injection Practices - How to Do It Right
Managing Patient Safety, One Injection at a Time
Check Your Steps! Make Every Injection Safe
Exploring Best Practices in Injection Safety


PPE Guidance when Administering Vaccines to Children
WHO's guidance on Infection prevention and control procedures for COVID-19 vaccination activities
IPC principles and procedure for COVID-19 vaccination activities

The Project Firstline program is a national training collaborative led by the Centers for Disease Control and Prevention (CDC) in partnership with ANA and the American Academy of Pediatrics, a 501(c)(3) nonprofit entity.

Want to learn more about Project Firstline? Contact

Project Firstline is a national collaborative led by the U.S. Centers for Disease Control and Prevention (CDC) to provide infection control training and education to frontline health care workers and public health personnel. ANA is proud to partner with Project Firstline, as supported through Cooperative Agreement CDC-RFA-OT18-1802. CDC is an agency within the Department of Health and Human Services (HHS). The contents of this webpage do not necessarily represent the policies of CDC or HHS and should not be considered an endorsement by the Federal Government.

As a key partner in this initiative, ANA is pleased to help bring critical training opportunities and resources to better equip all nurses with the tools necessary to provide optimal patient care in a safe environment. Placement of content on this website is not an endorsement of the source nor of any particular product or service, nor should it be construed as a statement that the source, or its products or services, are superior to those of any others. ANA and/or Project Firstline may not be the primary source of the content on this website. While we make every effort to provide up-to-date relevant content, resources or information may not have been updated yet to include recent changes, new findings, recommendations, or protocols.

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The American Nurses Foundation is a separate charitable organization under Section 501(c)(3) of the Internal Revenue Code. The Foundation does not engage in political campaign activities or communications.

The Foundation expressly disclaims any political views or communications published on or accessible from this website.

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