NSAIDS: The Difference Between COX-1 and COX-2
NSAIDs are a very common medication used to relieve pain, inflammation, and many other conditions. Dive into this article to read on for a clear overview of NSAID types and key safety considerations to help you support safer clinical decision making.
Course Details
Overview
As more patients live with multiple chronic conditions, you’ll encounter NSAIDs more often—making it essential to understand how to use them safely. In this article, you’ll learn how nonselective NSAIDs compare with COX-1 and COX-2 selective options, along with the key mechanisms of action, indications, and contraindications. With more knowledge, you’ll be ready to apply evidence-based guidance that reduces risk and helps protect your patients.
Key Learning Outcomes
- Differentiate selective COX-2 inhibitors from non-selective NSAIDs
- Explain how COX-1 and COX-2 inhibition affects various processes
- Apply nursing assessment skills to ensure safe NSAID use
Presented by:
Kim Kuebler, DNP, APRN, ANP-BC, FAAN
Kim Kuebler is an advanced practice provider in Brunswick, Georgia, and editor-in-chief of the Multiple Chronic Conditions Resource Center.

